New publication

A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance. Elpetra Timmermans contributed to this paper together with the UMCU. Felix van der Krift et al discribe a novel antifolate (C1) that, like Methotrexate, potentialy inhibits dihydrofolate reductase and downstream one-carbon metabolism. But C1 displays optimal efficacy in FPGS deficient contexts.