2023
Transcriptome sequencing reveals two subtypes of cortisol-secreting adrenocortical tumours in dogs and identifies CYP26B1 as a potential new therapeutic target.
Sanders K, Kooistra HS, van den Heuvel M, Mokry M, Grinwis GCM, van den Dungen NAM, van Steenbeek FG, Galac S. Vet Comp Oncol. 2023 Mar;21(1):100-110. doi: 10.1111/vco.12871. Epub 2023 Jan 16.PMID: 36582114
Reference intervals for plasma, urinary, and salivary concentrations of free metanephrines in dogs: Relevance to the diagnosis of pheochromocytoma.
van den Berg MF, Kooistra HS, Grinwis GCM, van Nimwegen SA, van Faassen M, Kema IP, Teske E, Galac S. J Vet Intern Med. 2023 Jan;37(1):173-183. doi: 10.1111/jvim.16624. Epub 2023 Jan 13.PMID: 36637037
Co-authorships:
Plasma and urinary metanephrine and normetanephrine concentrations using liquid chromatography with tandem mass spectrometry in healthy cats and in a cat with pheochromocytoma.
Prego MT, Dias MJ, Ferreira RL, Gonçalves S, Dias Domingues T, Junius G, Van den Steen E, Galac S, Leal RO. J Vet Intern Med. 2023 Apr 13. doi: 10.1111/jvim.16648. Online ahead of print.PMID: 37057306
Diagnosis, treatment and outcome of pheochromocytoma in a cat.
Prego MT, Dias MJ, Mestrinho L, Englar R, Grinwis G, Galac S, Leal RO.J Small Anim Pract. 2023 Mar 28. doi: 10.1111/jsap.13601. Online ahead of print.PMID: 36977649
2022
CDC6: A novel canine tumour biomarker detected in circulating extracellular vesicles.
Andriessen A, Bongiovanni L, Driedonks TAP, van Liere E, Seijger A, Hegeman CV, van Nimwegen SA, Galac S, Westendorp B, Nolte-‘t Hoen ENM, de Bruin A. Vet Comp Oncol. 2022 Jun;20(2):381-392. doi: 10.1111/vco.12781. Epub 2021 Nov 17.PMID: 34743398
Intratumoral injection of holmium-166 microspheres as neoadjuvant therapy of soft tissue sarcomas in dogs.
Morsink NC, Nijsen JFW, Grinwis GCM, Hesselink JW, Kirpensteijn J, van Nimwegen SA. Front Vet Sci. 2022 Nov 1;9:1015248. doi: 10.3389/fvets.2022.1015248. eCollection 2022.PMID: 36387397
Evaluation of PEG-L-asparaginase in asparagine suppression and anti-drug antibody development in healthy Beagle dogs: A multi-phase preclinical study.
Feenstra LR, Gehring R, van Geijswijk IM, König T, Prinsen HCMT, Vandemeulebroecke K, Lammens T, Krupa A, Teske E. Vet J. 2022 Aug;286:105854. doi: 10.1016/j.tvjl.2022.105854. Epub 2022 Jun 30.PMID: 3578107
Co-authorships:
Small molecules to regulate the GH/IGF1 axis by inhibiting the growth hormone receptor synthesis.
van der Velden LM, Maas P, van Amersfoort M, Timmermans-Sprang EPM, Mensinga A, van der Vaart E, Malergue F, Viëtor H, Derksen PWB, Klumperman J, van Agthoven A, Egan DA, Mol JA, Strous GJ. Front Endocrinol (Lausanne). 2022 Jul 28;13:926210. doi: 10.3389/fendo.2022.926210. eCollection 2022.PMID: 35966052
Association of recessive c.430G>A (p.(Gly144Arg)) thyroid peroxidase variant with primary congenital hypothyroidism in cats.
Van Poucke M, Van Renterghem E, Peterson ME, van den Berg MF, Stock E, Peelman LJ, Daminet S. J Vet Intern Med. 2022 Sep;36(5):1597-1606. doi: 10.1111/jvim.16524. Epub 2022 Aug 26.PMID: 36054182
2021
Evaluation of hypophysectomy for treatment of hypersomatotropism in 25 cats.
van Bokhorst KL, Galac S, Kooistra HS, Valtolina C, Fracassi F, Rosenberg D, Meij BP. J Vet Intern Med. 2021 Mar;35(2):834-842. doi: 10.1111/jvim.16047. Epub 2021 Feb 23.PMID: 33621385
Circulating MicroRNAs as Non-invasive Biomarkers for Canine Cushing’s Syndrome.
Sanders K, Veldhuizen A, Kooistra HS, Slob A, Timmermans-Sprang EPM, Riemers FM, Daminet S, Fracassi F, van Nimwegen SA, Meij BP, Galac S. Front Vet Sci. 2021 Nov 17;8:760487. doi: 10.3389/fvets.2021.760487. eCollection 2021.PMID: 34869733
Case Report: Radioactive Holmium-166 Microspheres for the Intratumoral Treatment of a Canine Pituitary Tumor.
Morsink NC, Klaassen NJM, Meij BP, Kirpensteijn J, Grinwis GCM, Schaafsma IA, Hesselink JW, Nijsen JFW, van Nimwegen SA. Front Vet Sci. 2021 Nov 4;8:748247. doi: 10.3389/fvets.2021.748247. eCollection 2021.PMID: 34805338
Treatment of canine oral papillary squamous cell carcinoma using definitive-intent radiation as a monotherapy-a case series.
van der Steen F, Zandvliet M. Vet Comp Oncol. 2021 Mar;19(1):152-159. doi: 10.1111/vco.12646. Epub 2020 Oct 1.PMID: 32975025
Feline and canine Merkel cell carcinoma: A case series and discussion on cellular origin.
van der Steen FEMM, Grinwis GCM, Weerts EAWS, Teske E. Vet Comp Oncol. 2021 Jun;19(2):393-398. doi: 10.1111/vco.12672. Epub 2021 Jan 16.PMID: 33372715
Co-authorships:
Quantitative dual-energy CT material decomposition of holmium microspheres: local concentration determination evaluated in phantoms and a rabbit tumor model.
Gutjahr R, Bakker RC, Tiessens F, van Nimwegen SA, Schmidt B, Nijsen JFW. Eur Radiol. 2021 Jan;31(1):139-148. doi: 10.1007/s00330-020-07092-1. Epub 2020 Aug 7.PMID: 32767101
Nanobody-targeted photodynamic therapy for the treatment of feline oral carcinoma: a step towards translation to the veterinary clinic.
Beltrán Hernández I, Grinwis GCM, Di Maggio A, van Bergen En Henegouwen PMP, Hennink WE, Teske E, Hesselink JW, van Nimwegen SA, Mol JA, Oliveira S. Nanophotonics. 2021 Aug 2;10(12):3075-3087. doi: 10.1515/nanoph-2021-0195. eCollection 2021 Sep.PMID: 3640550
Dedicated holmium microsphere administration device for MRI-guided interstitial brain microbrachytherapy.
de Vries M, Klaassen NJM, Morsink NC, van Nimwegen SA, Nijsen JFW, van den Dobbelsteen JJ. Med Eng Phys. 2021 Oct;96:13-21. doi: 10.1016/j.medengphy.2021.07.009. Epub 2021 Aug 12.PMID: 34565548
Molecular targets for anticancer therapies in companion animals and humans: what can we learn from each other?
Beltrán Hernández I, Kromhout JZ, Teske E, Hennink WE, van Nimwegen SA, Oliveira S. Theranostics. 2021 Feb 6;11(8):3882-3897. doi: 10.7150/thno.55760. eCollection 2021.PMID: 33664868
Medium-Throughput Drug- and Radiotherapy Screening Assay using Patient-Derived Organoids.
Putker M, Millen R, Overmeer R, Driehuis E, Zandvliet MMJM, Clevers H, Boj SF, Li QX.J Vis Exp. 2021 Apr 30;(170). doi: 10.3791/62495.PMID: 33999032
Comparison of methods to monitor dogs with hypercortisolism treated with trilostane.
Golinelli S, de Marco V, Leal RO, Barbarossa A, Aniballi C, Maietti E, Tardo AM, Galac S, Fracassi F.J Vet Intern Med. 2021 Nov;35(6):2616-2627. doi: 10.1111/jvim.16269. Epub 2021 Oct 21.PMID: 34672018
Feline plasma adrenocorticotropic hormone: validation of a chemiluminescent assay and concentrations in cats with hypercortisolism, primary hypoadrenocorticism and other diseases.
Tardo AM, Reusch CE, Galac S, Fornetti S, Tirolo A, Golinelli S, Shehdula D, Fracassi F.J Feline Med Surg. 2021 Feb;23(2):67-73. doi: 10.1177/1098612X20925686. Epub 2020 Jun 1.PMID: 32478637
2020
Feasibility of CT quantification of intratumoural 166Ho-microspheres.
C Bakker R, Bastiaannet R, van Nimwegen SA, D Barten-van Rijbroek A, Van Es RJJ, Rosenberg AJWP, de Jong HWAM, Lam MGEH, Nijsen JFW. Eur Radiol Exp. 2020 May 11;4(1):29. doi: 10.1186/s41747-020-00157-2.PMID: 32390070
Co-authorships:
Planar and single-photon emission computed tomography imaging in dogs with thyroid tumors: 68 cases.
van den Berg MF, Daminet S, Stock E, Vandermeulen E, Scheemaeker S, Campos M, Kooistra HS, Galac S, Duchateau L, Peremans K. J Vet Intern Med. 2020 Nov;34(6):2651-2659. doi: 10.1111/jvim.15908. Epub 2020 Sep 26.PMID: 32978987
Important publications 2010-2020
Abiraterone Acetate for Cushing Syndrome: Study in a Canine Primary Adrenocortical Cell Culture Model.
Sanders K, de Wit WL, Mol JA, Kurlbaum M, Kendl S, Kroiss M, Kooistra HS, Galac S. Endocrinology. 2018 Nov 1;159(11):3689-3698. doi: 10.1210/en.2018-00588.PMID: 30219917
The Utrecht Score: A novel histopathological scoring system to assess the prognosis of dogs with cortisol-secreting adrenocortical tumours.
Sanders K, Cirkel K, Grinwis GCM, Teske E, van Nimwegen SA, Mol JA, Hesselink JW, Kooistra HS, Galac S. Vet Comp Oncol. 2019 Sep;17(3):329-337. doi: 10.1111/vco.12474. Epub 2019 Apr 7.PMID: 30860644
Melanocortin 2 receptor antagonists in canine pituitary-dependent hypercortisolism: in vitro studies.
Sanders K, Mol JA, Kooistra HS, Galac S. Vet Res Commun. 2018 Dec;42(4):283-288. doi: 10.1007/s11259-018-9737-x. Epub 2018 Sep 5.PMID: 30187173
Molecular markers of prognosis in canine cortisol-secreting adrenocortical tumours.
Sanders K, van Staalduinen GJ, Uijens MCM, Mol JA, Teske E, Slob A, Hesselink JW, Kooistra HS, Galac S. Vet Comp Oncol. 2019 Dec;17(4):545-552. doi: 10.1111/vco.12521. Epub 2019 Aug 4.PMID: 31301217
P-cadherin mutations are associated with high basal Wnt activity and stemness in canine mammary tumor cell lines.
Timmermans-Sprang E, Collin R, Henkes A, Philipsen M, Mol JA. Oncotarget. 2019 Apr 26;10(31):2930-2946. doi: 10.18632/oncotarget.26873. eCollection 2019 Apr 26.PMID: 31105876
Molecular Signaling of Progesterone, Growth Hormone, Wnt, and HER in Mammary Glands of Dogs, Rodents, and Humans: New Treatment Target Identification.
Timmermans-Sprang EPM, Gracanin A, Mol JA. Front Vet Sci. 2017 Apr 13;4:53. doi: 10.3389/fvets.2017.00053. eCollection 2017.PMID: 28451590
Co-authorships:
Intratumoral treatment with radioactive beta-emitting microparticles: a systematic review.
Bakker RC, Lam MGEH, van Nimwegen SA, Rosenberg AJWP, van Es RJJ, Nijsen JFW.J Radiat Oncol. 2017;6(4):323-341. doi: 10.1007/s13566-017-0315-6. Epub 2017 Jun 24.PMID: 29213358
Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.
Driehuis E, Kolders S, Spelier S, Lõhmussaar K, Willems SM, Devriese LA, de Bree R, de Ruiter EJ, Korving J, Begthel H, van Es JH, Geurts V, He GW, van Jaarsveld RH, Oka R, Muraro MJ, Vivié J, Zandvliet MMJM, Hendrickx APA, Iakobachvili N, Sridevi P, Kranenburg O, van Boxtel R, Kops GJPL, Tuveson DA, Peters PJ, van Oudenaarden A, Clevers H. Cancer Discov. 2019 Jul;9(7):852-871. doi: 10.1158/2159-8290.CD-18-1522. Epub 2019 May 3.PMID: 31053628
Triggered radiosensitizer delivery using thermosensitive liposomes and hyperthermia improves efficacy of radiotherapy: An in vitro proof of concept study.
Besse HC, Bos C, Zandvliet MMJM, van der Wurff-Jacobs K, Moonen CTW, Deckers R. PLoS One. 2018 Sep 18;13(9):e0204063. doi: 10.1371/journal.pone.0204063. eCollection 2018.PMID: 30226898