Congrats to Maurice Zandvliet and colleagues from UMC Utrecht on their paper: Pre-existing subclones determine radioresistance in rectal cancer organoids. They use organoid technology and single-cell karyotype sequencing to track subclonal evolution in response to irradiation.

Congrats to Marit van den Berg and Sara Galac on their clinical review paper in Companion Animal: “Canine phaeochromocytoma: a guide to diagnosis and treatment”.

Kirsten van Bokhorst and colleagues published: Laparoscopic vs. open adrenalectomy: perioperative data and survival analysis in 70 dogs with an adrenal tumor in Front Vet Sci. Congrats!

Congrats to Marit van den Berg and her co-authors on their paper published in Frontiers: “Whole transcriptome analysis of canine pheochromocytoma and paraganglioma”. This article has been created through collaboration between Utrecht University and several veterinary faculties and centers, including Ghent University, University of Bologna, and Anicura Veterinary Clinic Roma Sud. Given the current lack…

Congrats to Hanna Versteegh on her paper in Animals: Feline Lymphoma: Patient Characteristics and Response Outcome of the COP-Protocol in Cats with Malignant Lymphoma in The Netherlands

A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance. Elpetra Timmermans contributed to this paper together with the UMCU. Felix van der Krift et al discribe a novel antifolate (C1) that, like Methotrexate, potentialy inhibits dihydrofolate reductase and downstream one-carbon metabolism. But C1 displays optimal efficacy in FPGS deficient contexts.

Karin Sanders won the second place in the category of basis/translational research for our paper “Transcriptome sequencing reveals two subtypes of cortisol-secreting adrenocortical tumors in dogs and identifies CYP26B1 as a potential new therapeutic target”.

Marit van den Berg received the award for oral abstract presented at the meeting of Society of Comparative Endocrinology at pre-meeting of ACVIM-Forum. Marit presented our work on culturing pheochromocytoma organoids.

Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification. Maurice Zandvliet contributed to this paper together with the Hubrecht institute and the UMCU. Rosemary Millen et al. expose organoids from head and neck cancer to chemo- and radiotherapy and a panel of targeted agents and…

Ultrasound and Microbubbles Mediated Bleomycin Delivery in Feline Oral Squamous Cell Carcinoma—An In Vivo Veterinary Study. Maurice Zandvliet, Stefanie Veraa and Tobion Restrepo contributed to a research paper by de Maar et al. In this small hypothesis-generating study, USMB plus chemotherapy was feasible and well-tolerated in a feline companion animal model and showed potential for…

Marit van den Berg presented her work on Whole Transcriptome Analysis of Canine Pheochromocytoma. She won first prize for her presentation! Chiron Morsink presented a poster entitled: Quantitative CT imaging and dose reconstruction of holmium-166 microspheres.